Objective:To investigated the correlation between galectin 3 and chronic heart failure classification,treatment and prognosis. Methods:Total of 140 patients with chronic heart failure in our hospital were selected from January 2011 to January 2013,and divided into NYHA class Ⅱ group(47 cases),Ⅲ level group(50 cases),Ⅳ level group(43 cases). Serum galectin-3,high sensitive C-reactive protein(hs-CRP)and N-terminal pro-brain natriuretic peptide (NT-proBNP)were detected. Left ventricular end-diastolic dimension (LVEDD)and ejection fraction (EF)were also observed. Serum galectin-3 level was compared between patients with ineffective and effective treatment results. Correction between prognosis and galectin-3 was analyzed. Results:Galectin-3 was positively correlated with hs-CRP,lnNT-proBNP,LVEDD,respevtively (r=0.912,P < 0.05;r=0.772,P < 0.05;r=0.564,P < 0.05),and negative correlated with EF(r=-0.612,P < 0.05). Serum galectin-3 level of effective treatment group was significantly higher than that of ineffective treatment group(t = 3.81,P < 0.01). And serum galectin-3 level of group with cardiac events was significantly higher than that of group without cardiac events(t = 3.04,P < 0.01). Conclusion:Galectin-3 is closely related to chronic heart failure,and could be used for clinical diagnosis of chronic heart failure.