Expression and clinical significance of Rab27b in colorectal cancer
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    Abstract:

    Objective: To detect the expression of Rab27b in human colorectal cancer (CRC) and investigate the relationship between Rab27b expression and clinical characteristics, especially the prognosis of CRC. Methods: Immunohistochemistry analysis by tissue microarrays (80 CRC samples and 20 tumor-adjacent tissue samples) was performed to characterize Rab27b expression in CRC. Cox regression and Kaplan-Meier survival analyses were carried out to evaluate the prognosis of CRC. Results: Immunohistochemistry analysis showed that the expression of Rab27b in CRC was significantly higher than that in normal tumor-adjacent tissues (P = 0.041). Moreover, the expression level of Rab27b protein in CRC was significantly related to gender (P = 0.012), serum CEA level (P = 0.014), distant metastasis (P = 0.021) and TNM stage (P = 0.013). COX multi-factor analysis showed that Rab27b expression (P = 0.021) could be recognized as an independent prognosis factor for CRC. Conclusion: Rab27b expression was abnormally highly expressed and correlated with malignant phenotypes of CRC. It may serve as a novel prognostic factor for CRC.

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倪沂江,秦 辉,汤黎明. Rab27b在结直肠癌中的表达情况及临床意义[J].南京医科大学学报(自然科学版英文版),2015,(10):1405-1408.

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History
  • Received:June 26,2015
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  • Online: October 28,2015
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