Objective:We aimed to explore sensitive serum biomarkers for the early evaluation of the occurrence and severity of bronchopulmonary dysplasia (BPD)by investigating the correlation between BPD and serum biomarkers including serum soluble receptor for advanced glycation end products (sRAGE)-endogenous secretory receptor for advanced glycation end products(esRAGE)-surfactant protein D(SP-D)and Clara cell 16 KD protein(CC-16)in the very low birth weight infants(VLBW). Methods The levels of sRAGE,esRAGE,SP-D and CC-16 in serum in 60 VLBW infants were detected by ELISA within 48 hours after birth.Meanwhile,we recorded their occurrence and valued the severity of BPD.Then we used statistical methods to analyze the correlation between serum biomarkers and the incidence and degree of BPD. Results:Compared with the normal control group,the levels of serum sRAGE and esRAGE increased significantly(P < 0.01)in the BPD group,while there was no significant difference in SP-D and CC-16 levels (P > 0.05).Additionally,the serum levels of sRAGE and esRAGE also showed statistic significance among the mild,moderate and severe BPD groups. Serum levels of sRAGE and esRAGE were not associated with gestational age. Conclusion:Serum levels of sRAGE and esRAGE can be early serum biomarkers for the occurrence and severity of BPD in VLBW infants.