Objective: To investigate the inhibitory effects of curcumin on the inflammation after myocardial infarction (MI) in rats and its underlying mechanisms. Methods: The Wistar rat MI models were established through the ligation of the left anterior descending coronary artery. Infiltration of inflammatory cells and the expression of related cytokines at different time points after MI were detected,and then we tried to uncover the underlying molecular mechanisms suppressing the inflammation by curcumin with Western blot. Results: Compared with the control group, the use of curcumin significantly improved cardiac function in 28 d after MI, and reduced the inflammatory cells infiltration of infarction area after MI 1 d, 7 d, 14 d and 28 d; further studies suggested that curcumin decreased inflammatory cytokines such as TNF-α, IL-1β and IL-6 in rats after MI at different times, and suppressed the activation of NF-κB and JAK-1/SATA3 signaling pathways. Conclusion: Curcumin can inhibit inflammation after MI by signaling pathways to reduce infiltration of inflammatory cells in infarct area and reduce the secretion of inflammatory cytokines, thus improve hemodynamics, reduce ventricular remodeling and maintain cardiac function.