Objective:To investigate the expression of FGFR4 mRNA in lung adenocarcinoma tissues and its association with prognosis. Methods:The quantitative expression of FGFR4 mRNA in 126 lung adenocarcinoma tissues and normal lung tissues in south China area were detected by real-time fluorescence quantitative-PCR,and the relationship between the quantitative expression of FGFR4 mRNA in lung adenocarcinoma and the prognosis were analyzed. Results:The expression of FGF4 mRNA in lung adenocarcinoma was significantly higher than that in normal lung tissues(P < 0.0001). The survival time of patients with lung adenocarcinoma with higher expression of FGFR4 mRNA was significantly longer than those with lower expression level of FGFR4 mRNA (P < 0.05). Conclusion:FGFR4 mRNA expression in lung adenocarcinoma of south China area was significantly down-regulated than that in tumor-adjacent normal lung tissue. Postoperative survival time of patients with lung adenocarcinoma in high FGFR4 mRNA expression was significantly longer than that with low expression.