Objective:To investigate the correlation of the plasma mRNA levels of the breast cancer susceptibility gene1(BRCA1)with clinicopathological parameters in patients with gastric cancer. Methods:The plasma BRCA1 mRNA was measured using quantitative reverse transcription polymerase chain reaction,and the relationship between BRCA1 level and clinicopathological parameters as well as survival was studied. Results:BRCA1 expression was not related to age,gender,TNM stage,tumor location,Lauren’s classification,vessel invasion,seros invasion,nerve invasion,differentation,surgical peocedures and sample sourse. However,BRCA1 level was associated with tumor size (P = 0.033)and overall survival of patients(P = 0.034). Conclusion:The plasma BRCA1 mRNA level could reflect certain information of gastric cancer including the tumor size and predict the overall survival.