Objective:To retrospectively summarize the clinic experiene of extracorporeal membrane oxygenation support for low cardiac output syndrom after heart surgery. Methods: From April 2010 to April 2014,23 patients received ECMO support,for the low cardiac output syndrom after heart surgery,were enrolled. The data were retrospectively obtained from our hospital database. Results:Fifteen patients(65.2% )weaned off successfully from ECMO, 10 patients (survival rate 43.5% )were discharged and 5 patients died of post-complications. Eight patients could not wean off from ECMO. Over all mean support time was 191 ± 121 hours. Bleeding,renal failure,lung infection and neurological complication were the most reported complications. The lactate levels before ECM0 support and the amount of blood loss in survivors and nonsurvivors had a significant difference(P < 0.05). Conclusion: ECMO is an effective mechanical assistant therapy method for severe cardiac and pulmonary failure after heart surgery.Earlier usage of ECMO and avoiding massive bleeding are the key point of success of ECMO.