Accumulating evidence showed that adipose inflammation plays an important role in obesity-associated metabolic disorders. As known, adipose tissue acts not only as an energy organ but also an endocrine organ, mainly consisting of fat cells, immune cells and other cells. Almost all of the immune cells participate in adipose inflammation, some of which are pro-inflammatory and others are anti-inflammatory. This review will summarize the participants in adipose inflammation, such as macrophages, T lymphocytes, dendritic cells, mast cells, eosinophils,and focus on the therapeutic potential of these adipose tissue immune cells in protecting from inflammation and obesity-related metabolic diseases will be discussed.