Objective:The aim of this study was to compare cephalometric measurements obtained from conventional cephalograms with synthesized cone beam CT (CBCT) cephalograms. Methods:Cephalometric analyses of 65 patients were conducted on conventional and CBCT-synthesized cephalograms at the same time. The lateral cephalograms were manually analyzed through the Dolphin Imaging 11.0TM software. Measurement results were compared and analyzed by paired t-test and test of goodness of fit. Results:Significant differences between the conventional cephalograms and synthesized CBCT cephalograms were found in all measurements except N-ANS/N-Me,ANS-Me/N-Me,L1-AP,IMPA,U1-SN and SNA (P < 0.05). The test of goodness of fit showed that the fitting degree of linear distance in 7 items was high,in 3 items was medium;the fitting degree of angle in 10 items was high,in 3 items was medium,in 2 items was low. It can be considered that there was a correlation between two kinds of measurement results except NP-FH and SGn-FH. Conclusion:Most measurements show correlation between conventional cephalograms and synthesized CBCT cephalograms.