Epigenetics is a discipline focusing on maintenance of phenotype through successive mitosis and the mechanisms mainly include DNA methylation and histone modification.Ubiquitin-like with PHD and ring finger domains 1(UHRF1)is a unique molecule,which is a main “hub protein” involved in epigenetic information integration as well as links DNA methylation and histone modification to ensure faithful epigenetic memory inheritance. Recent researches suggest that UHRF1 overexpression is abundant in many kinds of cancers,and it is involved in cancer occurrence and progression. This paper reviews the mechanism of epigenetics as well as the progress of UHRF1 in tumor diagnosis and treatment.