Objective:To explore the application of Donation after citizen’s death(DCD)and age-related marginal donor for liver transplantation in clinical liver transplantation. Methods:From December 2013 to October 2015,3 cases of DCD age-related marginal donors for liver transplantation were included in the Liver Transplantation Center,the First Affiliated Hospital of Nanjing Medical University. The clinical situation of liver transplantation was analyzed,retrospectively,including clinical data of both donors,and recipients, and short-term recovery of recipients. Results:Among the 3 cases,2 cases were performed by Chinese Ⅲ DCD ethical standard,and 1 cases was performed by Chinese Ⅱ DCD ethical standard. Among the 3 cases,one case was 7 years old,the other two cases were 79 years old and 83 years old. Three recipients recovered smoothly and liver function recovered well. The recipients by children liver appeared hallucinations,auditory hallucination and delusion of neuropsychiatric symptoms after 1 month,and healed after treatment. Conclusion:The study suggests that to some extent,as long as the scientific evaluation and reasonable application of the appropriate receptors,the liver transplantation of DCD marginal donors can obtain good results. Age should not be an independent taboo for liver transplant. On the basis of adequate assessment,the age-related marginal donor for liver transplantation is feasible.