Objective:To investigate the relationship between the serum vitamin D,parathyroid hormone and the heart rate-systolic blood pressure product (RPP)among adults. Methods:Based on the previous cross-sectional study,data analyses were carried out on 621 permanent residents aged≥40 years old. Analysis of variance and generalized liner model analysis were used to analyze the relationship between the 25 (OH)D,PTH and heart rate,systolic blood pressure,RPP. Results:Compared to participants with 25(OH)D≥20 μg/L,those with 25(OH)D<10 μg/L had higher heart rate and RPP,by increasing (5.0 ± 1.2) beats/min (P < 0.01)and(754.3 ± 187.8) beats/min-mmHg (P < 0.01),respectively. Among the high PTH group,heart rate increased 10.7 beats/min(P=0.001)and RPP increased 1 279.4 beats/min-mmHg(P=0.011)in participants with 25(OH)D<10 μg/L compared to those with 25(OH)D≥20 μg/L. After adjustment for age,gender and other variables,heart rate and RPP also increased 8.2 beats/min(P=0.017)and 1 041.8 beats/min-mmHg (P=0.06)in those with 25 (OH)D<10 μg/L. While in the low PTH group,heart rate and RPP increased 3.7 beats/min (P=0.018)and 639.5 beats/min-mmHg (P=0.007)respectively,and the adjusted RPP increased 595.7 beats/min-mmHg(P=0.012)in participants with 25(OH)D<10 μg/L compared to those with 25(OH)D≥20 μg/L. Conclusion:Vitamin D deficiency is associated with the increase of heart rate and RPP, which suggestes low vitamin D status may increase cardiac work,especially combination of vitamin D deficiency and elevated PTH maybe play a co-effect on the cardiac work.