Objective:To analyze the effect of nonuse of abdominal drainage in post hepatectomy of liver cancer. Methods:One hundred and thirteen patients who received resection of liver cancer were randomly designated to either experimental group (52 cases) or control group (61 cases). In the experimental group, the patients were not allowed to place the abdominal drainage;however, the patients in the control group underwent the use of the abdominal drainage conventionally. We observed the recovery of liver function after surgery, the time of the postoperative recovery, the length of hospital stay, the cost of hospital admission and postoperative adverse events and complications. Results:In the experimental group, the time of the postoperative recovery and the length of hospital stay were shorter than those in the control group, moreover, the cost of hospital admission was significantly reduced compared with the control group, all the differences reached statistical significance (P < 0.05). However, there were no differences of the recovery of liver function after surgery and postoperative adverse events and complications between two groups (P > 0.05). Conclusion:To the patients, nonuse of abdominal drainage after hepatectomy surgery is safe and effective,and this measure can accelerate the postoperative recovery of these patients. This measure can play an active role in ERAS (enhanced recovery after surgery) treatment.