Objective:To investigate the changes of adiponectin (ADPN),high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol(LDL-C) level in male patients with obstructive sleep apnea syndrome (OSAS). Methods:103 habitual snorers,participated in the study voluntarily. All the patients were male. All the patients were divided into 4 groups,according to apnea hypopnea index(AHI). There were simple snorers group(vehicle,n=21,AHI≤5),mild OSAS group(n=25,540). AHI and transcutaneous saturation oxygen (SpO2) were mornitored during the whole night and the concentration of APDN,HDL-C and LDL-C in serum were evaluated in the next morning. Results:There was no significant difference of age among the four groups (P > 0.05). Compared with vehicle,AHI in all three OSAS groups increased obviously (P < 0.01),while minSpO2 decreased markedly (P < 0.01). Compared with vehicle,however there was a trend to change of HDL-C and LDL-C in mild OSAS group,ANOVA did not show any significance (P > 0.05). Compared with vehicle,HDL-C decreased significantly and LDL-C increased obviously in moderate and severe OSAS group (P < 0.05,P < 0.01). In OSAS patients,AHI was negatively correlated with ADPN(r=-0.521,P < 0.01) and HDL-C(r=-0.344,P < 0.05) significantly,while it was positively correlated with LDL-C(r=0.326,P < 0.05) markedly. minSpO2 was positively correlated with ADPN(r=0.519,P < 0.01)and HDL-C(r=0.337,P < 0.05) significantly,while it was negatively correlated with LDL-C(r=-0.309,P < 0.05) obviously. Conclusion:OSAS can lower the concentration of ADPN and HDL-C,meanwhile it can elevate LDL-C in serum. The effect is associated with the increased AHI and decreased minSpO2.