Objective:To study the expression of vascular endothelial growth factor(VEGF) and it’s receptors FLT-1 and FLK-1 in rats with portal hypertensive gastropathy. Methods: Wistar rats were devided into two groups:PHG group whose portal hypertension was established by ligating the portal vein,and the sham-operation(SO)group served as control. After two weeks portal vein pressure was measured by physiological pressure capsule. Immunhistochemistry was used to detect the expression of VEGF and it’s receptors,and RT-PCR was used to detect the mRNA expression of VEGF and the receptors in both groups. Results: The pressure of PHG group was higher significantly than that in SO group(P < 0.05). And the PHG group has a significantly higher expressions of VEGF and the receptors compared with SO group(P < 0.05),the same of mRNA expressions. Conclusion: VEGF and the receptors may participate in the pathogenesis of portal hypertensive gastropathy.