Objective:To explore the change and relationship between serum homocysteine level and other common risk in acute ischemic stroke. Methods: According to the level of homocysteine,we divided 392 cases with acute ischemic stroke into two groups:ischemic stroke with hyperhomocysteinemia group (HHcy group,n=88 cases)and ischemic stroke with normal homocysteine level group (nHcy group,n=304 cases). The clinical characteristics,the level of blood glucose,blood lipid,uric acid,D-dimer and glycosylated hemoglobin (HbA1c)were retrospectively analyzed. Results:In the HHcy group,the male patients were more than the nHcy group. The level of serum homocysteine and HbA1c in the HHcy group was higher than the nHcy group,and the infarct size was larger than the nHcy group,all P < 0.05. The result of correlation analysis of serum homocystiene and other common risk factors showed that the level of Hcy was positively related to the level of uric acid and D-dimer.(r:0.144 and 0.129 respectively,all P < 0.05). Conclusions:Ischemic stroke caused by hyperhomocysteinemia is common in men and the infarct size more lager,and correlation to the level of uric acid and D-dimer