Objective:To explore the relationship between serum uric acid and islet beta cell function in newly diagnosed type 2 diabetes. Methods:We analyzed 605 newly diagnosed type 2 diabetes inpatients. We detected serum uric acid,cholesterol,triglyceride etc. and conducted OGTT and insulin release tests on each patient and total insulin level (InsAUC120),early phase insulin secretion index(INSR30),total insulin secretion index(INSR120)as well as beta cell function index(HOMA-β)were calculated. The population was divided into high and low uric acid groups respectively in the male and female groups. The relations between serum uric acid and InsAUC120,INSR30,INSR120 as well as HOMA-β were evaluated. Results:①The patient with hyperuricemia had higher InsAUC120,INSR30,INSR120 and HOMA-β than patient with hypouricemia;②The serum uric acid revealed significantly positive relationships with InsAUC120,INSR30,INSR120 and HOMA-β;③The correlations still existed after adjusting for possible influencing factors by multivariate regression analysis. Conclusion:Serum uric is an independent factor for indicating the islet beta cell secretion capacity and can play a potential serum marker of the insulin secretion ability.