Objective:To investigate the adherence status and interrelated factors of highly active antiretroviral therapy(HAART)on men who have sex with men(MSM)in Jiangsu province. Methods:Totally 184 new HIV AIDS patients who received antiretroviral therapy in 2013—2014 were recruited with purposive sampling method in this study. All participants were asked to complete one questionnaire. Results:Among the 184 HIV/AIDS patients,76.1% of participants had a good adherence to highly active antiretroviral therapy (HAART). Univariable analysis showed that employment,smoking and social support (family,friends and other support)were the relative factors which influence the adherence among HIV/AIDS patients. Multivariable analyses showed that employment,smoking,family and other support were the major risk factors (P < 0.05). Conclusion:The medication adherence to HAART of HIV/AIDS patients in MSM is low. The related professional departments should strengthen the compliance education before HAART.