Objective:To investigate the role of silent mating type information regulation 2 homolong1(SIRT1)activator SRT1720 in deoxycorticosterone acetate(DOCA)salt-sensitive hypertensive rats(DHR). Methods:A total of 28 male Sprague-Dawley rats underwent left nephrectomy were randomly divided into three groups:control group,model group,and SRT1720 treatment group. Control group(n=8):drinking water; model group(n=10)and SRT1720 treatment group (n=10):DOCA and silicone rubber medium at the concentration of 200 mg/kg was placed subcutaneously in rats on both sides of the scapula and given 1% NaCl drinking water. SRT1720 treatment group was given intragastric administration of SRT1720 for 4 weeks at the concentration of 100 mg/(kg·d). Systolic blood pressure(SBP)was measured once a week. After 4 weeks,central arterial pressure and pulse wave velocity (PWV)were monitored,and then rats were sacrificed. Thoracia aorta was taken for HE staining to observe the thickness and vascular caliber change. Results:In model group,SBP,central aortic pressure and PWV were significantly increased. HE staining showed marked vascular smooth muscle cell(VSMC)hypertrophy,and marked thickening of elastic fiber layer and aortic media,but a significantly decreasing in vessel diameter. Meanwhile,SRT1720 treatment group reversed these changes. Conclusion:SRT1720 could inhibit VSMC hypertrophy,reduce aortic media thickness,thereby expend blood vessel diameter,and reduce central arterial pressure and peripheral blood pressure in DOCA salt-sensitive hypertensive rats.