Objective:To explore the correlation between Lp-PLA2 combined with modified ABCD2 score and early neurological deterioration(END) in patients with mild ischemic stroke. Methods:A total of 180 patients with acute mild ischemic stroke were recruited in this study. All patients were evaluated by improved ABCD2 score for risk stratification,and the serum Lp-PLA2 level was detected by ELISA. Results:The level of Lp-PLA2 was significantly increased compared with that in the non END group (P < 0.05) . Lp-PLA2 was significantly related with improved ABCD2 score (P < 0.05). The Cox regression logistic regression model indicated that ABCD2 score (≥4),large artery stenosis (≥75%) and Lp-PLA2 (>200 ng/mL) were the predictive factors of END composite end points in mild cerebral ischemic stroke (P < 0. 05). Conclusion:Lp-PLA2 combined with modified ABCD2 score can improve the ability to predict the risk of END events in mild ischemic stroke.