With the introduction of curved linear array echoendoscope and the improvement of puncture equipments in the past decade,interventional endoscopic ultrasonography(EUS) based on EUS-guided fine needle aspiration has been rapidly evolved into a new minimally invasive therapeutic option. At present,novel EUS-based therapeutic interventions have been widely applied in the clinical practice. In this paper,we provide a comprehensive summary of the applications of interventional EUS in the management of pancreaticobiliary disease.