Objective:To investigate the relationship between the serum levels of sFlt-1,PLGF and their ratio in mild preeclampsia. Methods:We searched Wanfang,CNKI,PubMed,Embase and Cochran,and published domestic and foreign controlled studies about the relationship between the serum levels of sFlt-1,PLGF and their ratio in mild preeclampsia from 1994 to 2014. Then,we excluded non-compliant documents,and statistically analyzed the results of included studies using Review Manager 5.3 software. Results:A total of 17 studies were included in this study,including 14 Chinese studies and 3 English studies. Heterogeneity test about the serum levels of sFlt-1 expression and the relationship between mild preeclampsia was I2=96%,P< 0.000 01,and the heterogeneity was significant. The combined effect of SMD=4.89(95%CI:3.60~6.17),P < 0.000 01,the difference was statistically significant. Heterogeneity test about the serum levels of PLGF expression and the relationship between mild preeclampsia was I2=93%,P < 0.000 01,the heterogeneity was significant. The combined effect of SMD=-2.32(95%CI:-2.91~-1.72),P < 0.000 01,the difference was statistically significant. Heterogeneity test about the serum levels of sFlt-1/PLGF ratio expression and the relationship between preeclampsia was I2=98%,P < 0.000 01,the heterogeneity was significant,the combined effect of SMD=1.95(95%CI:0.50~3.40),P < 0.000 01,the difference was statistically significant. Conclusion:PLGF is highly correlated with the occurrence and development of mild preeclampsia;the serum levels of sFlt-1 expression associated with mild preeclampsia;sFlt-1 and sFlt-1/PLGF ratio can be used as an effective index for diagnosis of mild preeclampsia.