Objective:To investigaee the expressions of VEGF and EGFR and their associations with the clinical biological behavior in primary liver cancer. Methods:The protein expressions of VEGF and EGFR were detected in 63 primary liver cancer by immunohistochemistry streptavidin-perosidase(SP)methods. Results:①The positive expression rate of VEGF and EGFR was 63.5% and 50.8%,respectively.②The expression of VEGF was significantly correlated with Edmondson pathologic grade,portal vein tumor thrombus,tumor capsule and clinical stage(P < 0.05),while not with sex,age,AFP level,HBsAg status,liver cirrhosis,histological type and tumor size(P > 0.05).③EGFR expression was related to histological type,Edmondson pathologic grade,tumor mass and tumor capsule(P < 0.05). No correlation was found between EGFR expression and sex,age,AFP level,HBsAg status,liver cirrhosis,portal vein tumor thrombus,clinical stage(P > 0.05). Conclusion:VEGF and EGFR play an important role in the growth and metastasis of primary liver cancer.