Objective:To explore the risk factors of bloodstream infection in patients with hydrocarbon resistant Klebsiella pneumoniae(CRKP)and the risk factors of death in patients with Klebsiella pneumoniae bloodstream infection. Methods:Clinical data from 91 patients with Klebsiella pneumonia bloodstream infection were analyzed in the Second Affiliated Hospital of Nanjing Medical University from December 2009 to January 2014. The risk factors of CRKP were determined by the chi square test,and the risk factors for the death of Klebsiella pneumoniae bloodstream infection were determined by Logistic regression. Results:Im CRKP group,proportion of bloodstream infectied patients complicated by pneumonia(P=0.016),invasive mechanical ventilation(P=0.048)and ICU(P=0.017) was significantly higher than that im the SKP group and ESBLKP group. Univariate logistic regression analysis showed that WIC score≥3,malignant tumor,renal function imsufficiency,hypoproteinemia,deep vein set tube,with invasive mechanical ventilation,ICU admission,Pitt bacteremia score≥6 were the risk factors of death in patients with Klebsiella pneumoniae bloodstream infection. Multivariate logistic regression analysis showed that Pitt bacteremia score≥6 points(OR=509.891,P < 0.001)was an independent risk factor of patients died of Klebsiella pneumoniae bloodstream infection. Conclusion:With pneumonia,invasive mechanical ventilation and ICU stay were risk factors for CRKP-producing bloodstream infection;Pitt bacteremia score≥6 was the independent risk factor of patients died of Klebsiella pneumoniae bloodstream infection.