Objective:The mortality and PYLL of malignancies in Jiangsu province in 2013 were studied to provide basic data for cancer prevention and control. Methods:Death case information related to malignancies and demographic information was collected through Provincial Death Cause Surveillance System and police department,disease burden of malignancies and its population distributive characteristics were analyzed by calculating mortality,standardized mortality,PYLL and SPYLL,etc. Results:Totally 135 236 cases were died of malignant tumor,which accounted for 29.38%. Arnong the sabjects,86 736 cases were male and 48 500 cases were female. The crude and standardized mortality were 196.80/100 000 and 111.59/100 000,respectinely the male to female ratio of crude mortality was 1.77,while the urban to rural ratio was 0.95,and the top five were lung cancer,stomach cancer,esophageal cancer,liver cancer,and colorectal cancer,which accounted for 75.54% of all. PYLL and SPYLL was 788 367 and 582 620.68 people*years,respectively,the male to female ratio of PYLL was 1.78,while the urban to rural ratio was 0.93. Liver cancer,lung cancer,stomach cancer,esophagus cancer and leukemia were the top five,however,breast cancer had replaced the fourth place of esophagus cancer in the female. Conclusion:The leading malignancies related to death and early death in the whole population were lung cancer,gastric cancer,esophageal cancer,liver cancer,colorectal cancer and leukemia,as well as breast cancer in the female. Malignant tumor mortality and PYLLR of the male was much higher than those of the female,and those of the rural residents was slightly higher than those the urban of. Preventive interventions should focus on key population and malignancy with higher mortality burden.