Objective: To investigate the effects of construction of the central vascularized artificial bone with β-tricalcium phosphote and explore the mechanism of vascularization in artificial bone for its further clinical application. Methods: We built a model by implanting the selected New Zealand rabbits lumbar dorsal artery side channel of the β-tricalcium phosphate， filled with the autologous tiny bone particles， and flushed the latissimus dorsi muscle bag. Pure artificial bone was put into every rabbit’s lift latissimus dorsi muscle bag as the control group. The samples were taken out for spiral CT， X-ray， and histology after 4， 8， and 12 weeks. Results: The site where the implanted vascular bundles appeared like foramen nutriens， the blood vessels were abundant， which emerged from deep tissue of the artificial bone were evident on the surface specimen， the central vascularized tricalcium phosphte were filled with new-born vessels at 4-8 weeks. Newly formed bone appeared after 4 weeks and was more mature at 12 weeks. There were only a few new-born vessels in control. Four weeks postoperatively， there were no significant differences on CT， X-ray， and histological grading between the experimental group and the control group （P>0.05）； 8， 12 weeks postoperatively， the difference was significant on CT， X-ray， and histological grading between the experimental group and the control group （P<0.05）. Conclusion: Putting an artery into central axis of the artificial bone and implanting the artificial bone into rabbit’s latissimus dorsi muscle can notably improve vascularization of artificial bone. This method can be used to build model of vascularized bone.