Objective:Microbubble is a kind of traditional contrast agent for ultrasound imaging and also one of the most important probe carriers for ultrasound molecular imaging. The developing trend of molecular probes on microbubbles is to multimodal,multifunctional and intelligent. Now there have been lots of novel and multifunctional molecular probes developed based on microbubbles in recent years. This review summarized the design and application of different types of ultrasound molecular probes. It includes multimodal molecular probes of various imaging modes,multifunctional molecular probes of integration of diagnosis and therapy,stimulated response ultrasound molecular probes triggered by special pathological conditions and enhanced tissue penetration ultrasound molecular nano-probes.