Objective：To study the role of IKKα in macrophages in renal inflammation after renal ischemia-reperfusion injury(IRI)in mice model.Methods：A total of 20 C57BL/6 wild type (WT) mice and 20 IKKαMKO (KO) mice (healthy，male，and aged 8～10 weeks) were randomly divided into the control (Sham) group and the renal IRI group，respectively.The morphology change of renal tissue and the infiltration of inflammatory cells were observed by hematoxylin and eosin (HE) staining.The expressions of interleukin 10(IL-10)，interleukin 6(IL-6)，Ki67，CD68，iNOS，and Arg-1 were detected by immunohistochemistry.The protein expressions of IL-10 and IL-6 were detected by Western blotting.Results：Compared with the Sham group，obvious renal tissue injury and increasing inflammation infiltration were observed in the IRI group by HE staining. Immunohistochemical results on expressions of both IL-10 and IL-6 were increased after renal IRI occurred，IL-10 increased while IL-6 decreased by time.Compared with the WT-IRI group，the renal pathological damage was more severe (P＜0.01)，the expressions of IL-6，CD68 and iNOS were significantly increased (P＜0.01)，but the expressions of IL-10 (P＜0.01) and Ki67 (P＜0.05) were distinctly decreased in the KO-IRI group.Conclusion：IKKα knockout in macrophages aggravates renal ischemia-reperfusion injury and inhibits renal repair in mice model，which can be related to intensifying the early infiltration and inflammatory reaction of macrophages(M1 mainly).