Objective：To evaluate the prognostic significance of perineural invasion (PNI) in patients with early cervical cancer. Methods：We reviewed clinical records and pathology slides of 306 patients with cervical cancer(FIGO IA2IIA2) after radical hysterectomy in Department of Gynecology，Jiangsu Provincial People′s Hospital From January 2008 to December 2015. Results：①The incidence of PNI in patients with early cervical cancer was 10. 5%(32/306). ②The incidence of PNI was correlated with tumor diameter，depth of invasion，lymphovascular spare invasion (LVSI) and lymph node metastasis(P＜0.05). ③The disease-free survival and overall survival of the PNI-positive group were significantly lower than those of the PNI-negative group. ④Univariate analysis showed that tumor diameter，PNI and clinical stage were correlated with the overall survival time of cervical cancer(P＜0.05). The tumor diameter was correlated with disease-free survival time (P=0.002). ⑤Multivariate analysis showed that PNI was not identified as an independent risk factor(P=0.154). Conclusion：The PNI is associated with tumor diameter，depth of invasion，LVSI and lymph node metastasis，and affect the prognostic of cervical cancer，but is not an independent risk factor.