The mechanism study of enhancer RNA inducing inflammatory response in unexplained recurrent spontaneous abortion
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    Abstract:

    Objective: To screen the differently expressed miRNAs study the expression andfunction of let-7f-5p in unexplained recurrent spontaneous abortion (URSA) and investigate the roles of miRNAs played in URSA. Methods: The miRNA-sequencing was applied to screen miRNAs that differently expressed in URSA placental villous; The qRT-PCR was used to validate the miRNA’s expression of screened miRNAs; The DAVID was applied to analyze pathway; The qRT-PCR was conducted to measure the expression of target genes in p53 pathway. Results: The expression of let-7f-5p was markedly up-regulatedhighly expressed in URSA placental villous; The targets of let-7f-5p were abundant in p53 pathway, and the expression of MDM-X and MDM2 was significantly down-regulated, while the expression of p53 was significantly up-regulated. Conclusion: let-7f-5p might promote cell apoptosis in URSA by regulating the expression of MDM-X/MDM2/p53 in p53 pathway.

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梁 婕,韩 莉,梁 健,凌 敏,卞 倩. let-7f-5p在不明原因复发性流产绒毛组织中的表达及其功能研究[J].南京医科大学学报(自然科学版英文版),2017,(8):971-975.

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History
  • Received:October 17,2016
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  • Online: August 17,2017
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