The role of duodenal-jejunal anastomosi and duodenal-jejunal bypass on RBP-4 in rats with type 2 diabetes
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    Abstract:

    Objective: To detect the serum levels of retinol binding protein-4 (RBP-4) and glucose transporter-4 (GLUT-4) in the short-time (8 weeks) after duodenal-jejunal anastomosi (DJA) surgery and duodenal-jejunal bypass (DJB) surgery for type 2 diabetic rats,and attempt to explore theoretical basis and mechanisms of surgical treatment in type 2 diabetes. Methods: Type 2 diabetic rats were divided into the DJA surgery group (n=10), the DJB surgery group (n=10) and the sham surgery group (n=10). Weight, food intake, fasting blood glucose, fasting insulin, and RBP-4 level were measured before and after treatment. The glucose metablolism and insulin resistance before and after operation were evaluated. GLUT-4 level was detected at the 8th week after surgery. Results: Compared with the sham surgery group, the DJB and DJA groups showed decreased fasting blood glucose, reduced area under oral glucose tolerance test(OGTT) curve, improved insulin resistance, decreased BRP-4 level, and increased GLUT-4. Conclusion: DJA and DJB operation could significantly improve the glucose metabolism and insulin sensitivity of type 2 diabetic rats, which were independent of the weight loss, but related to decreased RBP-4 and increased GLUT-4 in skeletal muscle.

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卜和美,马向华,孙 婧,方 达.十二指肠空肠旁路术与十二指肠空肠吻合术对2型糖尿病大鼠视黄醇结合蛋白4的作用及意义[J].南京医科大学学报(自然科学版英文版),2017,(9):1148-1153.

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  • Received:June 20,2017
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  • Online: September 25,2017
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