Objective：To investigate gene polymorphsim of human leukocyte antigen G (HLA-G) 3’ untranslated regions (3’-UTR) in Uygur，Xinjiang. Methods：Genomic DNA was extracted from 100 blood samples of Uygur population. Amplification of HLA-G 3’-UTR was performed by PCR. The productions were directly sequenced to analyze the frequency of genotypes and haplotypes.Results：There were 98 samples sequenced successfully.Ten single nucleic polymorphisms were found in HLA-G 3'UTR in Uygur populations consisting of 14bpDel/Ins，+3003C/T，+3010C/G，+3027A/C，+3035C/T，+3092T/G，3121T/C，+3142C/G，+3187A/G and +3196C/G. Strong linkage disequilibrium existed among these SNPs. It showed a higher HLA-G 3’-UTR haplotype diversity including 20 haplotypes and UTR-2 was the most one (24.9%). Conclusion：Polymorphisms and haplotypes of HLA-G 3’-UTR were distinct in Uygur populations. The data provide fundamental and critical information to explore mechanism of HLA-G in the role of genetics，evolution，immunity function and related diseases.