Objective: To compare the clinical outcomes of patients with normal ovarian function in vitro fertilization and embryo transfer therapy, using clomiphene citrate combined with low dose gonadotropin regimen and conventional antagonist regimen. Methods: A prospective randomized controlled trial was conducted. One hundrend and tweenty couples were selected from September 2014 to December 2015 at the First Affiliated Hospital of NJMU, the normal ovarian function of the woman and the in vitro fertilization embryo transfer therapy. The women were divided into experimental group (clomiphene citrate combination low dose gonadotropin regimen) and control group (conventional antagonist regimen) according to the randomized digital envelope method. Both of the two groups All embryo were frozen and frozen-thawed embryos were transfered, followed-up to live or running out of all embryos of this cycle in two groups, compare the clinical and laboratory results and clinical outcomes of the two groups were compared. Results: The dosage of gonadotropin in the experimental group was lower than that in the control group. The stimulate time of gonadotropin was shorter than that of the control group. There was no significant difference in clinical pregnancy rate and cumulative live birth rate between two groups. Conclusion: The combination of clomiphene citrate and low dose gonadotropin program can achieve the clinical outcome as good as the conventional antagonist regimen in the case of reduced dosage of gonadotropin and shortened stimulation days. It is a new economical, effective and mild ovulation induction program.