Objective：Through the difference of clinical and endoscopic feature，to explore the diagnosis between the patients with MALT lymphoma and diffuse large B cell lymphoma in the gastrointestinal tract. Methods：A total of 119 patients with MALT lymphoma and diffuse large B cell lymphoma in the gastrointestinal tract proven by pathology from January 2009 and to July 2016，were retrospectively analyzed. Results：Of the 119 cases，The male-to-female ratio of MALT lymphoma and DLBCL were respectively 1.73：1，≈1 and the median age was 55 years. However，MALT lymphoma and DLBCL were both mainly involved in the stomach，but the most frequent site of MALT lymphoma was body of the stomach，as to DLBCL，antrum of the stomach was the most frequent site. The most common symptom of MALT lymphoma and DLBCL was both abdominal discomfort，followed by weight loss，gastrointestinal bleeding and so on. The diagnosis rate of gastrointestinal endoscopy was 74.8%. Patients with MALT lymphoma diagnosed by EMR/ESD were more than patients with DLBCL（P=0.006），and the two groups diagnosed by the way of biopsy and surgical had no statistical difference（P > 0.05）. Endoscopic performance mainly presented as ulcerative type，mucosal uplift type，superficial type，tumer-like and polypoid type. The most common type of the two groups was both ulcerative type. MALT lymphoma was 73.2% in stageⅠ ~ Ⅱand DLBCL was 42.3% in stageⅠ ~ Ⅱ. There was statistically significant difference between the two groups（P=0.001）.The patients with higher level of LDH were significantly more common in DLBCL than in MALT lymphoma（P=0.002）. In addition，the positive rate of MALT lymphoma group and DLBCL group respectively were 53.1%，46.5%. Conclusion：Patients with MALT lymphoma and DLBCL were varied in clinical manifestations. The rate of endoscopic diagnosis was high and the ways of endoscopic diagnosis included biopsy，EMR or ESD of large organizations. The most common endoscopic lesion was ulcerative type. Patients with MALT lymphoma diagnosed by EMR/ESD were more than patients with DLBCL，and clinical staging of MALT lymphoma are early and DLBCL are advanced. The patients of high levels of LDH in DLBCL are more than MALT lymphoma.