Objective：This systematic review and Meta-analysis aimed to investigate the metastatic rate of hilar lymph node and mediastinal lymph node in clinical stage Ⅰ non-small-cell lung cancer patients with either pure ground-glass opacity（Pure-GGO）or mixed ground-glass opacity（Mixed-GGO），therefore to indicate how to dissect lymph nodes in patients with GGO. Methods：A systematic search of the published literature was conducted using the main databases（Science Direct，PubMed，Springer Link and Wiley Online Library）to collect relevant case-control studies that compared Pure-GGOs and Mixed-GGOs in clinical stage I non-small-cell lung cancer patients. Meta-analysis was performed extracting data from the published literature using STATA 12.0. The results of the Meta-analysis were expressed as an odds ratio（OR）and their corresponding 95% confidence interval（CI）. Results：We extracted data from three case-control studies，with a total of 736 patients. There was no significant difference（OR=3.66，95% CI：0.68-19.58，P=0.13）in the rates of metastases in all lymph nodes in patients with either Pure-GGO or Mixed-GGO. In addition，there were no significant differences（OR=4.22，95% CI：0.77-23.19，P=0.10）in the rates of metastases in hilar lymph nodes in patients with either Pure-GGO or Mixed-GGO，but one study showed an OR of 20.18（95% CI：0.94-432.12）. There was no significant difference in rates of metastases of mediastinal lymph nodes in patients with either Pure-GGO or Mixed-GGO（OR=1.10；95% CI：0.19-6.32，P=0.92）. Conclusion：The results indicated no statistically significant difference in metastatic rates of hilar lymph nodes and mediastinal lymph nodes in patients with either Pure-GGO or Mixed-GGO. However，as thoracic surgeon，we must be particularly cautious about metastasis in hilar lymph nodes in patients with Mixed-GGO.