Objective：To investigate the association between serum lipoprotein-associated phospholipase A2（LP-PLA2）and coronary atherosclerosis. Methods：A total of 119 inpatients from the Second Affiliated Hospital of NMU were selected in this study. Eighty-three patients with coronary atherosclerosis were included in the coronary lesion group，and 36 people without coronary atherosclerosis were included in the negative group. LP-PLA2 was detected by enzyme kinetic method，high sensitive C-reaction protein（hs-CRP）was detected by enzyme linked immunosorbent assay（ELISA），and the level of D-Dimer was detected by immune turbidimetry. The patients in the case group were divided into three groups including 1 branches，2 or 2 branches lesion + left main lesion，and 3 or 3 branches lesion according to the number of diseased coronary artery. The severity of coronary artery lesion was evaluated by the Gensini integrations. Results：The serum levels of LP-PLA2，hs-CRP and D- Dimer in the case group were significantly higher than those in the control group（P < 0.05）. The levels of LP-PLA2 and hs-CRP were significantly different between patients with different severity of coronary lesions（P < 0.05）. Furthermore，Pearson correlation analysis showed that LP-PLA2 and hs-CRP had a low-level positive correlation with Gensini score（r=0.418，r=0.365，P < 0.05）. Conclusion：The levels of serum LP-PLA2，hs-CRP and D-Dimer were correlated with coronary atherosclerosis. For patients with coronary atherosclerosis，serum levels of LP-PLA2 and hs-CRP can only provide a limited reference value in assessing the extent of coronary artery lesions.