Objective：To explore the variation of hand-foot-mouth disease（HFMD）in China from 2008 to 2014 and provide implements for preventing the disease. Methods：The HFMD data from 23 provinces，5 autonomous regions and 4 municipalities was obtained from National Center for Disease Control and Prevention according to month. Standard deviation ellipse，median center and hot-spot analyses were employed to analyze HFMD data. Results：①During the year 2008 to 2014，it was reported 11 814 830 HFMD cases，with an average growth rate of 125.55 per 100 thousandth.②The outbreak of HFMD was in April to July and September to November，but different regions had different characteristics.③There were higher HFMD incidence rate in southeastern areas with double peaks than that in northwestern areas with single peak.④HFMD incidence rate had an increasing trend in southern areas. Conclusion：There was a dominantly regional difference at period of incidence and diffusion. Thus，different provinces should implement prevention and control measures to reduce the incidence and mortality depended on its characteristics.