Objective：To systematically evaluate the intervention effect of health education on prevention of mother to child transmission of acquired immune deficiency syndrome（AIDS） in childbearing women in China. Methods：We retrieved full text databases at home and abroad by computer and collected relevant literature on the health education in preventing mother-to-child transmission of HIV among childbearing women in China from January 1，2010 to December 31，2015. Rev Man 5.0.23 software and meta analysis method were performed to comprehensively quantitatively analyze 19 included studies. Results：After health education intervention，the total awareness rate of prevention of mother to child transmission of HIV among childbearing women in China increased by 41%（Z=7.84，P<0.001），the rate of the correct attitude held increased by 22%（Z=4.08，P=0.008），and the positive behavior change rate increased by 27%（Z=5.12，P < 0.001）. Subgroup analysis showed that the effect of health education in low baseline was better than that in high baseline（χ2=68.31，P < 0.001），the effect of positive health education was better than that of general health education（χ2=40.96，P < 0.001），and the effect of health education with high quality research and low quality research was similar（χ2=0.29，P=0.840）. Conclusion：Health education intervention has significant effect on improving the awareness rate of knowledge in preventing mother-to-child transmission of HIV，the correct attitude and behavior change rate of childbearing women in China.