Phosphoinositol 3-kinase（PI3K）/ serine threonine protein kinase（Akt）signaling pathway is one of the important signaling pathways in the body，which can regulate the biological activity of cell growth，proliferation and apoptosis. A large number of studies have shown that activation of PI3K / Akt signaling pathway is involved in inflammatory responses and regulation of immune responses. Akt is a key downstream protein of the PI3K signaling pathway. Therefore，the mechanism of Akt downstream protein on the regulation of inflammatory diseases such as shock，sepsis and ischemia-reperfusion injury is helpful to find a potential target for the treatment of these diseases.