Objective：To investigate the effect of astragaloside IV combined with enalapril on cardiac function after acute myocardial infarction（AMI）in mice. Methods：Twenty-four 8-week old male C57BL/6 mice were randomly divided into 4 groups，including the sham group，the CTL group，the enalapril group and the AS-IV+enalapril group. The CTL group，the enalapril group and the AS-IV+enalapril group were subjected to left anterior descending coronary artery ligation as AMI model. Mice in the enalapril group（enalapril 7.5 mg/kg）and the AS-IV+enalapril group（AS+IV 10 mg/kg + enalapril 7.5 mg/kg）were treated with the corresponding medicine，respectively. Echocardiography was applied to measure cardiac function 2 weeks later. Pathological changes of heart were studied by HE staining. CD31/ VEGFR3 double immunofluorescent staining were used to observe the density of vessels and angiogenesis. Results：Compared to the CTL group，the cardiac function was significantly improved in the enalapril group and the AS-IV+enalapril group，especially the latter one. Compared to the CTL group，there was significantly more angiogenesis to be observed in the peri- infarction region of the enalapril group and the AS-IV+enalapril group. This effect was better in the AS-IV+enalapril group. Conclusion：Astragaloside-IV combined with enalapril can effectively improve the cardiac function of mice after myocardial infarction and promote the regeneration of blood vessels in the peri-infarction region.