RNA-binding motif 4（RBM4） is an RNA-binding protein（RBP） that involves in different cell biological processes. Its structure contains two RNA recognition motifs and a CCHC-type zinc finger. RBM4 is expressed in a variety of tissues，at least in the process of post-transcriptional gene regulation，such as selective splicing of precursor mRNA，translational control and RNA silencing. RBM4 has a variety of biological functions，including maintaining embryonic and gonadal development，controlling circadian rhythms and mediating cell differentiation. Abnormal expression of RBM4 can lead to the occurrence of multiple diseases，especially in relation to tumors，but the specific mechanism needs further study. This article will review the research progress of RBM4.