Taurine protects against angiotensinⅡ⁃induced hypertension.
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    Abstract:

    Objective:To investigate if taurine has the protective effect on angiotensinⅡ-induced hypertension. Methods:AngiotensinⅡosmotic mini-pumps were implanted to mice subcutaneously to induce hypertension. Caudal arterial pressure was tested,and Hematoxylin-eosin staining and Masson staining were performed to determine the effect of taurine on hypertension and hypertension induced vascular remodelling;the mRNA levels of fibrotic markers were determined by RT-PCR;Western blot was performed to investigate the effect of taurine on molecular mechanisms of angiotensinⅡ-induced hypertension and hypertension induced vascular remodelling. Results:Taurine inhibited angiotensinⅡ-induced hypertension and consequent vascular remodelling,reduced the mRNA levels of fibrotic markers,and inhibited the MAPK pathway during the process. Conclusion:Taurine cowd inhibit MAPK pathway to attenuate angiotensinⅡ-induced hypertension and consequent vascular remodelling.

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沈烨娇,陆 艳,孙 伟,孔祥清.牛磺酸对血管紧张素Ⅱ诱导的高血压的保护作用[J].南京医科大学学报(自然科学版英文版),2018,(8):1017-1021,1076.

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History
  • Received:December 27,2017
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  • Online: August 15,2018
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