Objective：To investigate if taurine has the protective effect on angiotensinⅡ-induced hypertension. Methods：AngiotensinⅡosmotic mini-pumps were implanted to mice subcutaneously to induce hypertension. Caudal arterial pressure was tested，and Hematoxylin-eosin staining and Masson staining were performed to determine the effect of taurine on hypertension and hypertension induced vascular remodelling；the mRNA levels of fibrotic markers were determined by RT-PCR；Western blot was performed to investigate the effect of taurine on molecular mechanisms of angiotensinⅡ-induced hypertension and hypertension induced vascular remodelling. Results：Taurine inhibited angiotensinⅡ-induced hypertension and consequent vascular remodelling，reduced the mRNA levels of fibrotic markers，and inhibited the MAPK pathway during the process. Conclusion：Taurine cowd inhibit MAPK pathway to attenuate angiotensinⅡ-induced hypertension and consequent vascular remodelling.