Forkhead box protein O1（FoxO1），as an important cell transcription factor，is involved in many biological processes including cell cycle arrest，apoptosis and DNA damage repair by regulating the expression of target genes. The expression of FoxO1 is closely related to tumorigenesis，development and prognosis. FoxO1 is widely expressed in human tissues such as lung，heart，liver，pancreas，skeletal muscle，testis and ovary. This article reviews the recent research progress of FoxO1 in non-small cell lung cancer.