Influenza A virus is the main type of seasonal influenza and influenza pandemics in history. It has been widely researched at home and abroad. China has also been recognized as a new and multiple influenza virus place，which is also the outpost of world influenza surveillance. Influenza surveillance in China plays an important role in the world. The researchers use functional genomics screening and case-control study to find some genes which can affect the human influenza virus infection or aggravate the condition of patients with influenza through a variety of pathogenic mechanisms. Mutation of the host gene can affect the toxicity and the spreading of influenza A virus，which also has great effects on susceptibility to influenza. The study on susceptibility gene of influenza A，at the level of host genetic to find the pathogenesis of influenza A，in order to further explore the pathogenesis of influenza virus invasion of the host，which contributes to carry out influenza prevention and control work.