Objective：To explore the expression and significance of FOXO1 in mature B-cell neoplasms. Methods：The expression of FOXO1 in mature B-cell neoplasms was mined in Oncomine database. The different expressions of FOXO1 between the normal tissue and B-cell neoplasms were analyzed by BIOGPS database. The survival time of patients with mature B-cell neoplasms was detected by GEPIA. The FOXO1 interacting proteins were analyzed by String-DB database. Results：At the mRNA level，FOXO1 was lower in mature B-cell neoplasms than in normal tissue，and the expression level was not notable correlated with the prognosis of mature B-cell neoplasms（Logrank P=0.39）. FOXO1 related proteins are EP300、JUN、MYC、STAT1、FOS、SPI1、E2F，etc. Conclusion：The information of FOXO1 expression in mature B-cell neoplasms could be quickly extracted by using data mining and would be an scientific and theoretical support for the further research.