Objective：To discover unknown LncRNAs associated with Coronary Artery Disease（CAD）in peripheral blood. Methods：Three pairs of clinical CAD group and control blood plasma samples were texted in this experiment by high-throughput sequencing methods. Cuffdiff software was used to get the expression profiles of LncRNAs，differentially expressed LncRNAs were identified based on fold change and p-value. Differently expressed genes in peripheral plasma and blood monocytes were verified by Q-PCR in 36 pairs of clinical CAD group and controls. Results：The optimal 45 up-regulated and 29 down-regulated LncRNAs were detected. Three LncRNAs uc003pxg.1，ENST00000565257，ENST00000568324 were up-regulated obviously in peripheral blood mononuclear cells of CAD patients. Area under the ROC curve results of uc003pxg.1，ENST00000565257，ENST00000568324 were 0.812 5，0.742 4，0.742 4 respectively. These genes were all up-regulated in CAD patients obviously and these outcomes were consistent with the sequencing results. Conclusion：The ideal LncRNAs were detected preliminarily. This founding lays the foundation for further research，and provides theoretical basis of LncRNA using for CAD early clinical screening.