Objective：The aim of the present study was to evaluate the relationship of lipoprotein-associated phospholipase A2（Lp-PLA2）with the severity and prognosis of non-ST-elevation acute coronary syndromes（NSTE-ACS）. Methods：We conducted a hospital-based study to examine the potential association of Lp-PLA2 with the severity and prognosis of NSTE-ACS. A total of 157 unrelated subjects（46 UAP patients，49 Non-STEMI patients and 62 non-CAD subjects as control）who underwent elective coronary angiography from January 2014 to May 2015 admitted to Department of Cardiology，the Affiliated Jiangning Hospital of NMU. Results：We observed that the plasma levels of Lp-PLA2 were significantly higher among non-ACS patients compared to non-CAD subjects，moreover，its level is most high in Non-STEMI patients. There was also a highly remarkable association of Lp-PLA2 with double-vessel and triple-vessel disease when patients were divided into subgroups based on the number of diseased vessels. After 1-year follow up，we found that Lp-PLA2 levels were also related to events of MACE with statistical significance. Conclusion：Our results suggest that Lp-PLA2 is associated with the severity and prognosis of NSTE-ACS.