The intestinal floras and their metabolites play an important role in cardiovascular disease（CVD）. Changes in the composition of intestinal floras and their metabolites are related to the occurrence and development of atherosclerosis，myocardial infarction，heart failure，and hypertension. The mechanism of the effects of intestinal floras and their metabolites on CVD has been reported. This article will review the role and mechanism of intestinal floras and their metabolites in the development and progression of atherosclerosis，myocardial infarction，heart failure，and hypertension，as well as the potential value in the prevention and treatment of CVD，providing new insights into the prevention and treatment of CVD.