Objective：To evaluate the effects of ridge preservation in non-molar sites with advanced periodontitis，and to compare the effects of Bio-Oss，Bio-Gene and equal-ratio mixed of both materials. Methods：A total of 26 patients with 32 non-molar regions who were diagnosed with advanced periodontitis at our institution were included. They were classified into three experimental groups and one control group. The experimental groups were grafted with Bio-Oss，or Bio-Gene or the equal-ratio mixed of both materials after the tooth extraction，while the control group did not graft any meterials. Clinical and CBCT parameters were measured before，immediately and 6 months after the extraction. Data statistics used one-way ANOVA and LSD-t analysis. Results：The alveolar ridges of the control group were narrow，while the experimental groups were relatively plump at 6 months after the extraction. The difference of changes of alveolar bone height and width among the control and experimental groups was statistically significant（P＜0.05）. The changes of alveolar bone height，width and density postoperatively of the mixed group were minimal，then was the Bio-Oss group，and last was the Bio-Gene group. The difference among the experimental groups was statistically. Conclusion：Ridge preservation after the extraction was superior in the maintenance of soft and hard tissues. The equal-ratio mixed of Bio-Oss and Bio-Gene was better than either one alone.