Research progress of long non⁃coding RNA in cervical cancer
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    Abstract:

    The occurrence and development of cervical cancer is a complex pathological process. In addition to HPV infection,oncogene activation and inactivation of suppressor genes play an important role in the cancer process. LncRNAs are long RNA transcripts,which are longer than 200 nucleotides and are unable to encode proteins. Some lncRNAs are abnormally expressed in tumors and can be involved in the cellular pathways regulation as oncogenes or tumor suppressor genes,and are closely related to its development and metastasis. There are growing evidences that some lncRNAs are abnormally expressed in cervical cancer cells,and there are various ways to regulate their proliferation,migration and apoptosis. LncRNAs are closely related to tumor size,angiogenesis,FIGO late stage,lymph node metastasis and poor prognosis of cervical cancer. They are important indicators for diagnosis and prognosis,and also are potential therapeutic targets.

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张 琰,金 华,王适之.长链非编码RNA在宫颈癌中的研究进展[J].南京医科大学学报(自然科学版英文版),2019,(2):306-312.

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History
  • Received:July 19,2018
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  • Online: March 06,2019
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